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UK could get ‘94.5% effective’ Moderna vaccine by next spring

A ‘TREMENDOUSLY exciting’ US coronavirus vaccine that may offer very high levels of protection against Covid-19 could arrive in the UK as early as next spring, the government has said.

British scientists have hailed the news that it may be 94.5 per cent effective against the illness.

Interim data suggests the jab, from US firm Moderna, is highly effective in preventing people getting ill and may work across all age groups, including the elderly.

The UK has already secured 40million doses of a vaccine from Pfizer/BioNTech, which uses the same technology as Moderna and should be in the UK before Christmas.

‘Best news’: Moderna joins Pfizer after announcing a vaccine that has more than 90 per cent efficacy PICTURE: GETTY

A government spokesman said: ‘The news from Moderna appears to be good and represents another significant step towards finding an effective Covid-19 vaccine.

‘As part of the ongoing work of the Vaccines Taskforce, the government is in advanced discussions with Moderna to ensure UK access to their vaccine as part of the wider UK portfolio.

‘Moderna are currently scaling up their European supply chain which means these doses would become available in spring 2021 in the UK at the earliest.’

Scientists said the news boded well for other Covid-19 vaccines, with the one for Oxford University and UK pharmaceutical giant AstraZeneca due to report in the coming days or weeks.

Moderna intends to submit an application for an emergency-use authorisation with the US Food and Drug Administration shortly and will submit further data on the vaccine’s effectiveness and safety.

The firm’s final-stage clinical trial is ongoing and includes more than 30,000 people in the US.

The interim analysis included 95 participants with confirmed cases of Covid-19, of whom 90 had received the placebo and five the active vaccine.

Effective: A scientist working on the Moderna coronavirus vaccine PICTURE: PA

The 95 cases included 15 aged 65 and over as well as 20 people who were not white, including 12 from Hispanic or Latino/a backgrounds, four African-Americans, three Asian-Americans and one who was multiracial.

Severe cases of coronavirus were also examined, including 11 in the first interim analysis.

All 11 cases occurred in the placebo group and none in the group that had received the vaccine, known currently as mRNA-1273.

Moderna said its available data did not indicate any significant safety concerns.

However, the 94.5 per cent efficacy from this analysis could drop as further results from the clinical trial are announced.

Dr Stephen Hoge, president of Moderna, said he ‘grinned ear to ear’ when learning about the potential efficacy of the vaccine.

He told BBC News: ‘When we got the news from the data and safety monitoring board I’ll admit I broke character and grinned ear to ear for a minute.

‘Because I didn’t expect… I don’t think any of us really hoped that the vaccine would be 94 per cent effective at preventing Covid-19 disease, that was really a stunning realisation.’

He said combined with data suggesting it could stop severe Covid-19, it meant ‘the vaccine really is a terrific tool for stopping the pandemic and hopefully stopping the worst of the disease that people are facing’.

He added: ‘When you combine it with the news of last week of Pfizer’s vaccine, you’ve got now two vaccines that are over 90 per cent effective.

Rollout: It is hoped the vaccine can begin to be distributed in the early part of the new year PICTURE: GETTY

‘It really means I think we have the tools necessary to finally beat this virus back and I think that’s probably the best news of the day for all of us, that there really are now solutions in our hands and we need to deliver them to the people who can use them.’

Dr Hoge told BBC Radio 4’s World At One programme the firm was ‘looking forward to being able to supply substantial quantities of the vaccine to the UK government’.

Pressed on whether the rollout could be done quickly, he replied: ‘It depends a little on concluding those negotiations. I don’t want to get too far ahead of ourselves.

‘But we do have the ability to supply in the early part of next year and certainly we hope substantial quantities by the spring.’

No.10 said the UK had worked on agreements with vaccine developers who offered ‘different types of vaccines, can provide early supply to the UK and have advanced manufacturing supply chains in place’.

At the end of October, Moderna announced that the UK’s Medicines and Healthcare products Regulatory Agency (MHRA), which approves jabs, had started the rolling review process of its vaccine.

Peter Openshaw, professor of experimental medicine at Imperial College London, said: ‘This news from Moderna is tremendously exciting and considerably boosts optimism that we will have a choice of good vaccines in the next few months.

‘First we heard 90 per cent efficacy from Pfizer and BioNTech, then the Russians said 92 per cent and now Moderna says 94.5 per cent.

‘This latest press release is based on a study of 30,000 US adults, including many high-risk or elderly persons.

‘This gives us confidence that the results are relevant in the people who are most at risk of Covid-19 and in most need of the vaccines.

‘Moderna have also announced that the vaccine can be kept in a conventional freezer (-20C) for up to six months, and that once thawed the vaccine can be kept for up to 30 days at standard refrigeration (2 to 8C). This makes the vaccine much easier to deliver.’

‘Exciting’: Top scientists have hailed the latest vaccine news as very encouraging PICTURE: GETTY

Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine, said: ‘This announcement from Moderna is a further encouragement that vaccines will be found to not only have an acceptable efficacy, but an efficacy that is much greater than we had anticipated.

‘As with previous announcements, this is encouraging for other vaccines that may be expected to also have worthwhile efficacy.

‘Although they reported efficacy being over 94 per cent, there is statistical uncertainty in this, but based on these data, the likely efficacy will be better than 85 per cent which would be greater than most scientists would have expected.

‘This is the first study to report on severe cases and while uncertainty remains, the finding of no severe cases with the vaccine and 11 cases with placebo is very strong evidence that the vaccine prevents severe as well as mild disease.’

He said more data was needed on the elderly ‘but this is definitely encouraging progress’.

Professor Trudie Lang, from the University of Oxford, said: ‘It is very good news indeed to see another vaccine coming through with similar efficacy results as were reported last week from Pfizer.

‘These early results suggest that there was a representation across different age groups and diverse communities in the protected group.’